diff --git a/chrome/browser/extensions/api/chrome_extensions_api_client.cc b/chrome/browser/extensions/api/chrome_extensions_api_client.cc
index f61ec524109fe..0ac0d2fae56a9 100644
--- a/chrome/browser/extensions/api/chrome_extensions_api_client.cc
+++ b/chrome/browser/extensions/api/chrome_extensions_api_client.cc
@@ -290,6 +290,7 @@ void ChromeExtensionsAPIClient::OpenFileUrl(
   Navigate(&navigate_params);
 }
 
+#if BUILDFLAG(ENABLE_GUEST_VIEW)
 AppViewGuestDelegate* ChromeExtensionsAPIClient::CreateAppViewGuestDelegate()
     const {
   return new ChromeAppViewGuestDelegate();
@@ -322,6 +323,7 @@ ChromeExtensionsAPIClient::CreateWebViewPermissionHelperDelegate(
     WebViewPermissionHelper* web_view_permission_helper) const {
   return new ChromeWebViewPermissionHelperDelegate(web_view_permission_helper);
 }
+#endif  // BUILDFLAG(ENABLE_GUEST_VIEW)
 
 #if BUILDFLAG(IS_CHROMEOS)
 std::unique_ptr<ConsentProvider>
diff --git a/chrome/browser/extensions/api/chrome_extensions_api_client.h b/chrome/browser/extensions/api/chrome_extensions_api_client.h
index 56568a6fa50c8..84822e4b43864 100644
--- a/chrome/browser/extensions/api/chrome_extensions_api_client.h
+++ b/chrome/browser/extensions/api/chrome_extensions_api_client.h
@@ -6,6 +6,7 @@
 #define CHROME_BROWSER_EXTENSIONS_API_CHROME_EXTENSIONS_API_CLIENT_H_
 
 #include "base/memory/raw_ptr.h"
+#include "build/build_config.h"
 #include "build/chromeos_buildflags.h"
 #include "extensions/browser/api/extensions_api_client.h"
 
@@ -52,6 +53,7 @@ class ChromeExtensionsAPIClient : public ExtensionsAPIClient {
                         const Extension& extension) override;
   void OpenFileUrl(const GURL& file_url,
                    content::BrowserContext* browser_context) override;
+#if BUILDFLAG(ENABLE_GUEST_VIEW)
   AppViewGuestDelegate* CreateAppViewGuestDelegate() const override;
   ExtensionOptionsGuestDelegate* CreateExtensionOptionsGuestDelegate(
       ExtensionOptionsGuest* guest) const override;
@@ -64,6 +66,7 @@ class ChromeExtensionsAPIClient : public ExtensionsAPIClient {
       WebViewGuest* web_view_guest) const override;
   WebViewPermissionHelperDelegate* CreateWebViewPermissionHelperDelegate(
       WebViewPermissionHelper* web_view_permission_helper) const override;
+#endif  // BUILDFLAG(ENABLE_GUEST_VIEW)
 #if BUILDFLAG(IS_CHROMEOS)
   std::unique_ptr<ConsentProvider> CreateConsentProvider(
       content::BrowserContext* browser_context) const override;
diff --git a/extensions/shell/browser/shell_extensions_api_client.cc b/extensions/shell/browser/shell_extensions_api_client.cc
index 0bf1ad71ea362..267e4b0c46ae7 100644
--- a/extensions/shell/browser/shell_extensions_api_client.cc
+++ b/extensions/shell/browser/shell_extensions_api_client.cc
@@ -33,6 +33,7 @@ void ShellExtensionsAPIClient::AttachWebContentsHelpers(
   ShellExtensionWebContentsObserver::CreateForWebContents(web_contents);
 }
 
+#if BUILDFLAG(ENABLE_GUEST_VIEW)
 AppViewGuestDelegate* ShellExtensionsAPIClient::CreateAppViewGuestDelegate()
     const {
   return new ShellAppViewGuestDelegate();
@@ -42,6 +43,7 @@ WebViewGuestDelegate* ShellExtensionsAPIClient::CreateWebViewGuestDelegate(
     WebViewGuest* web_view_guest) const {
   return new ShellWebViewGuestDelegate();
 }
+#endif  // BUILDFLAG(ENABLE_GUEST_VIEW)
 
 std::unique_ptr<VirtualKeyboardDelegate>
 ShellExtensionsAPIClient::CreateVirtualKeyboardDelegate(
diff --git a/extensions/shell/browser/shell_extensions_api_client.h b/extensions/shell/browser/shell_extensions_api_client.h
index 409c1cacd572d..2ce760952efac 100644
--- a/extensions/shell/browser/shell_extensions_api_client.h
+++ b/extensions/shell/browser/shell_extensions_api_client.h
@@ -27,9 +27,11 @@ class ShellExtensionsAPIClient : public ExtensionsAPIClient {
   // ExtensionsAPIClient implementation.
   void AttachWebContentsHelpers(content::WebContents* web_contents) const
       override;
+#if BUILDFLAG(ENABLE_GUEST_VIEW)
   AppViewGuestDelegate* CreateAppViewGuestDelegate() const override;
   WebViewGuestDelegate* CreateWebViewGuestDelegate(
       WebViewGuest* web_view_guest) const override;
+#endif  // BUILDFLAG(ENABLE_GUEST_VIEW)
   std::unique_ptr<VirtualKeyboardDelegate> CreateVirtualKeyboardDelegate(
       content::BrowserContext* browser_context) const override;
   std::unique_ptr<DisplayInfoProvider> CreateDisplayInfoProvider()